circRNA basic information
circBase ID: -
Name: hsa_circ_LTBP1
Synonym: Circ-LTBP1
Host Gene: hsa-miR-107
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: doxorubicin-induced intracellular toxicity in cardiomyocytes
Species: human
Species details: human
Sample type: cell line
Sample type details: Human cardiomyocyte-like AC16 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-107
Biological function: ROX induced the proliferation inhibition, inflammation, apoptosis, and oxidative stress in AC16 cells, which were rescued by circ-LTBP1 inhibition or miR-107 upregulation.
Molecular mechanism: MiR-107 was confirmed as a target of circ-LTBP1,Circ-LTBP1 mediated ADCY1 expression by sponging miR-107 in AC16 cells.
Survival: -
Supported No.:
 2
Description:

Circ-LTBP1 was found to enhance DOX-induced effects on proliferation inhibition, inflammation, apoptosis, and oxidative stress in AC16 cells through competitively sponging miR-107 and elevating ADCY1.
Other information
Title:

Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal.

Journal: Mol Cell Biochem
Published: 2022/1/26
PubMed ID: 35076816