circRNA basic information
circBase ID: hsa_circ_0010235
Name: -
Synonym: circ_0010235
Host Gene: hsa-miR-1249-3p
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human LUAD cell lines (H1650, H1299), normal bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1249-3p
Biological function: Silencing of circ_0010235 hindered LUAD cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, as well as diminished tumor growth in vivo
Molecular mechanism: circ_0010235 targeted and inhibited hsa-miR-1249-3p. HOXA13 was identified as a direct and functional target of hsa-miR-1249-3p.
Survival: -
Supported No.:
 1
Description:

Our findings demonstrate that the circ_0010235/miR-1249-3p/HOXA13 axis is implicated in the pathogenesis of LUAD.
Other information
Title:

Identification of a Novel circ_0010235/miR-1249-3p/HOXA13 Axis in Lung Adenocarcinoma.

Journal: Biochem Genet
Published: 2022/1/26
PubMed ID: 35076814