circRNA basic information
circBase ID: -
Name: hsa_circ_CPM
Synonym: circCPM
Host Gene: hsa-miR-21-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC 5_FU sensitive cells (AGS, HGC_27), resistant cell lines (AGS_5FU, HGC_27_5FU)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-21-3p
Biological function: Silencing circCPM greatly improved chemosensitivity in vitro and in vivo.
Molecular mechanism: it directly binds to hsa-miR-21-3p in the cytoplasm and therefore increases the expression of PRKAA2, contributing to the activation of autophagy and chemoresistance.
Survival: poor
Supported No.:
 1
Description:

Our results reveal that circCPM has a crucial role in regulating GC autophagy and 5-FU resistance by targeting PRKAA2. It may function as a new theory basis for assessing the curative effect of GC and reversing 5-FU chemoresistance.
Other information
Title:

Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy.

Journal: Clin Transl Med
Published: 2022/1/26
PubMed ID: 35075806