circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD36
Synonym: CircANKRD36
Host Gene: hsa-miR-599
 
 
 
Disease basic information
DO ID:
 62
DO name: aortic valve disease
Disease details: calcific aortic valve disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-599
Biological function: Inhibiting the expression of differentiation-related factors of VIC osteogenesis and the formation of calcified nodules.
Molecular mechanism: CircANKRD36 can inhibit the expression of hsa-miR-599 and the activation of TGF-beta signaling pathway
Survival: -
Supported No.:
 1
Description:

circANKRD36 can inhibit the expression of miR-599 and the activation of TGF-beta signaling pathway, thus inhibiting the expression of differentiation-related factors of VIC osteogenesis and the formation of calcified nodules. Therefore, circANKRD36-miR-599-TGF-beta axis can be a new theoretical basis for treating CAVD.
Other information
Title:

Mechanism of CircANKRD36 regulating cell heterogeneity and endothelial mesenchymal transition in aortic valve stromal cells by regulating miR-599 and TGF-beta signaling pathway.

Journal: Int J Cardiol
Published: 2022/1/26
PubMed ID: 35074490