circRNA basic information
circBase ID: -
Name: hsa_circ_ROBO1
Synonym: circROBO1
Host Gene: hsa-miR-217-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BC cell lines (BT-549, MDA-MB-231, MDA-MB-468, MCF-7, T-47D, SKBR-3), normal breast epithelial cell line (MCF-10A, 293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217-5p
Biological function: Knockdown of circROBO1 strikingly inhibited the proliferation, migration, and invasion of BC cells, whereas overexpression of circROBO1 showed the opposite effects._oreover, overexpression of circROBO1 promoted tumor growth and liver metastasis in vivo.
Molecular mechanism: circROBO1 could upregulate KLF5 by sponging hsa-miR-217-5p, allowing KLF5 to activate the transcription of FUS, which would promote the back splicing of circROBO1.
Survival: poor
Supported No.:
 1
Description:

Our results demonstrated that circROBO1 facilitates the carcinogenesis and liver metastasis of BC through the circROBO1/KLF5/FUS feedback loop, which inhibits the selective autophagy of afadin by suppressing the transcription of BECN1. Therefore, circROBO1 could be used not only as a potential prognostic marker but also as a therapeutic target in BC.
Other information
Title:

The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin.

Journal: Mol Cancer
Published: 2022/1/26
PubMed ID: 35073911