circRNA basic information
circBase ID: -
Name: hsa_circ_ACAP2
Synonym: CircRNA-ACAP2
Host Gene: hsa-miR-143-3p
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human astrocytes (NHA), neuroblast cell lines (IMR-32, SK-N-SH)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-143-3p
Biological function: Silencing ACAP2 significantly constrained neuroblastoma cell migration, invasion, and glycolysis, and promoted apoptosis.
Molecular mechanism: circ-ACAP2 sponged hsa-miR-143-3p to downregulate its expression in neuroblastoma cells.
Survival: -
Supported No.:
 1
Description:

Our study revealed biological roles and molecular mechanisms for circ-ACAP2 in the oncogenic characteristics of neuroblastoma, facilitating the development of circRNA-based treatment approaches for anti-brain tumor therapy.
Other information
Title:

CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis.

Journal: Transl Pediatr
Published: 2022/1/25
PubMed ID: 35070838