circRNA basic information
circBase ID: -
Name: hsa_circ_ACC1
Synonym: -
Host Gene: hsa-miR-29c-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: lung epithelial cell line (BEAS-2B), NSCLC cell lines (H1299, H2170, A549, H1703)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MCL-1
Associated microRNA: hsa-miR-29c-3p
Biological function: promotes NSCLC Proliferation
Molecular mechanism: circACC1/hsa-miR-29c-3p/MCL-1, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Elevated levels of circACC1 were found in NSCLC patients and were negatively correlated with OS. Ectopic expression of circACC1 promoted the capacity of cell growth and clonogenicity, while the inhibition of circACC1 decreased the proliferation and clonogenicity potential.
Other information
Title:

CircACC1 Promotes NSCLC Proliferation via miR-29c-3p/MCL-1 Signaling Pathway.

Journal: Front Genet
Published: 2022/1/25
PubMed ID: 35069696