circRNA basic information
circBase ID: -
Name: hsa_circ_DLGAP4
Synonym: circDLGAP4
Host Gene: hsa-miR-143
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NB SH-SY5Y cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-143
Biological function: exosomal circDLGAP4 enhanced glycolysis and drug resistance
Molecular mechanism: circDLGAP4 was validated to act as a sponge for the HK2-targeting hsa-miR-143.
Survival: -
Supported No.:
 1
Description:

In conclusion, these findings demonstrate that exosome-delivered circDLGAP4 promotes the glycolysis, proliferation, and invasion of sensitive NB cells by regulating miR-143 and HK2, providing a novel link between drug resistance and circDLGAP4/miR-143/HK2 axis in drug-resistant NB.
Other information
Title:

Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma.

Journal: Cancer Biomark
Published: 2022/1/25
PubMed ID: 35068445