circRNA basic information
circBase ID: -
Name: hsa_circ_PTPN12
Synonym: circPTPN12
Host Gene: hsa-miR-21-5p
 
 
 
Disease basic information
DO ID:
 10881
DO name: hand, foot and mouth disease
Disease details: keloid
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: keloid fibroblasts, normal fibroblasts were separated from keloid tissues, normal tissues.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-21-5p
Biological function: circPTPN12 knockout could enhance the multiplication, migration, invasion, and decline apoptosis of keloid fibroblasts.
Molecular mechanism: hsa-miR-21-5p could be packed with circPTPN12 sponge, SMAD7 was downstream effect factor of hsa-miR-21-5p
Survival: -
Supported No.:
 1
Description:

Taken together, silencing circPTPN12 promotes the growth of keloid fibroblasts by activating Wnt pathway targeting miR-21-5p. CircPTPN12 may play a considerable part in keloid formation, which supplies a reference for molecularly targeted therapy keloid.
Other information
Title:

Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p.

Journal: Bioengineered
Published: 2022/1/25
PubMed ID: 35068324