circRNA basic information
circBase ID: hsa_circ_0000135
Name: -
Synonym: circ_0000135
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: cervical cancer cell lines (HeLa 229, MS751, SiHa), human cervical epithelial cell (HcerEpic)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-140-3p
Biological function: sh-circ_0000135 group had decreased cell viability, arrested cells in G0/G1 phase, decreased CyclinD1 expression, inhibited cell migration and invasion; sh-circ_0000135 group showed reduced tumor volume, weight, and lower Ki67 expression
Molecular mechanism: circ_0000135 had conserved target of hsa-miR-140-3p. hsa-miR-140-3p might have direct interaction with PDZK1.
Survival: -
Supported No.:
 1
Description:

circ_0000135 may play an anti-tumor role on the progression of cervical cancer by sponging miR-140-3p to suppress the expression of PDZK1, providing a promising therapeutic target.
Other information
Title:

Roles of circ_0000135/miR-140-3p/PDZK1 network in cervical cancer.

Journal: Clin Transl Oncol
Published: 2022/1/24
PubMed ID: 35066758