circRNA basic information
circBase ID: -
Name: hsa_circ_TMX4
Synonym: circ-TMX4
Host Gene: hsa-miR-622
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung cancer cell lines (H1299, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-622
Biological function: increase lung cancer cell invasion
Molecular mechanism: ERbeta-promoted circ-TMX4 could then sponge and inhibit the micro RNA (miRNA, miR), hsa-miR-622, expression, which can then result in increasing the CXCR4
Survival: -
Supported No.:
 1
Description:

Together, our findings suggest that ERbeta can promote NSCLC cell invasion via altering the ERbeta/circ-TMX4/miR-622/CXCR4 signaling, and targeting this newly circ-TMX4/miR-622/CXCR4 signaling may help us find new treatment strategies to better suppress NSCLC progression.
Other information
Title:

Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression.

Journal: Cell Death Dis
Published: 2022/1/23
PubMed ID: 35064116