circRNA basic information
circBase ID: -
Name: hsa_circ_PHACTR4
Synonym: circPHACTR4
Host Gene: hsa-miR-34b-5p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 786-O, A498, HEK-293
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-34b-5p
Biological function: increase the cancer stem cell (CSC) population
Molecular mechanism: Mechanism dissection revealed that ERbeta could suppress circular RNA PHACTR4 (circPHACTR4) expression via direct binding to the estrogen response elements (EREs) on the 5 promoter region of its host gene, phosphatase and actin regulator 4 (PHACTR4) to decrease hsa-miR-34b-5p expression.
Survival: -
Supported No.:
 1
Description:

Together, these results suggest that ERbeta may increase CSC population in ccRCC via altering ERbeta/circPHACTR4/miR-34b-5p/c-Myc signaling and that targeting this newly identified signal pathway may help physicians to better suppress ccRCC progression.
Other information
Title:

Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.

Journal: FASEB J
Published: 2022/1/22
PubMed ID: 35061326