circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-599
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (SHG_44, U251, A172)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-599
Biological function: hsa_circ_0000285 promoted cell proliferation and migration, it inhibited apoptosis
Molecular mechanism: hsa_circ_0000285 sponged hsa-miR-599, which negatively regulated GNG12 by binding to its mRNA.
Survival: -
Supported No.:
 7
Description:

Hsa_circ_0000285 is overexpressed in the glioma and promotes its progression by directly regulating the miR-599/GNG12 axis. This novel mechanism, therefore, shows that the hsa_circ_0000285/miR-599/GNG12 axis may be a promising therapeutic target for glioma treatment.
Other information
Title:

Circular RNA hsa_circ_0000285 regulates the microRNA-599/G-protein subunit gamma 12 (miR-599/GNG12) axis to promote glioma progression.

Journal: J Clin Lab Anal
Published: 2022/1/22
PubMed ID: 35060646