circRNA basic information
circBase ID: -
Name: hsa_circ_PDZD8
Synonym: circ_PDZD8
Host Gene: hsa-miR-516b-5p
 
 
 
Disease basic information
DO ID:
 3905
DO name: lung carcinoma
Disease details: Lung carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: lung carcinoma cell lines (A549, PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-516b-5p
Biological function: Circ_PDZD8 might overturn the repression of Lido on cell growth ability and metastasis in this tumor.
Molecular mechanism: circ_PDZD8 might regulate GOLT1A expression by sponging hsa-miR-516b-5p.
Survival: -
Supported No.:
 1
Description:

Circ_PDZD8 might mitigate the inhibitory effect of Lido on tumor cell malignancy by modulating the miR-516b-5p/GOLT1A axis, providing a novel insight for lung carcinoma treatment.
Other information
Title:

Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis.

Journal: Histol Histopathol
Published: 2022/1/22
PubMed ID: 35060113