circRNA basic information
circBase ID: -
Name: hsa_circ_FGFR1
Synonym: circFGFR1
Host Gene: hsa-miR-224-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: primary normal human astrocytes (NHA), glioma cell lines (U251MG, U87MG, U118MG, T98G, SNB19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-224-5p
Biological function: circFGFR1 is elevated in glioma cells, resulting in aggravated glioma aggravated malignancy.
Molecular mechanism: hsa-miR-224-5p directly binds to circFGFR1 and CXCR4 mRNA.
Survival: -
Supported No.:
 1
Description:

our findings suggest that circFGFR1 plays a critical role in the tumorigenic behaviors in glioma cells by upregulating CXCR4 expression via sponging to hsa-miR-224-5p. These findings provide a new perspective on circRNAs during GBM development.
Other information
Title:

Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p.

Journal: J Immunol Res
Published: 2022/1/22
PubMed ID: 35059468