circRNA basic information
circBase ID: hsa_circ_0000221
Name: hsa_circ_VIM
Synonym: circ-0000221
Host Gene: hsa-miR-661
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Hep-G2, SNU449
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-661
Biological function: the introduction of exogenous_sa-circ-0000221_nto Hep-G2 or SNU449 cell lines results in detectable decrease in cellular viability and an increase in apoptotic manifestations
Molecular mechanism: tumor-suppressive role of_sa-circ-0000221_n HCC, which acts through hsa-miR-661 inhibition, along with a subsequent PTPN11 mRNA increase
Survival: -
Supported No.:
 1
Description:

Our study encourages further investigation of the role of circRNAs in cancer and their potential use as molecular biomarkers.
Other information
Title:

Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661-PTPN11 mRNA Axis.

Journal: Pharmaceutics
Published: 2022/1/22
PubMed ID: 35057034