circRNA basic information
circBase ID: -
Name: hsa_circ_HECTD1
Synonym: circHECTD1
Host Gene: hsa-miR-335
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: Ischemic stroke
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cerebral microvascular endothelial cells (HCMECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-335
Biological function: silencing of circHECTD1 remarkably reversed OGD/R-induced promotion of HCMEC tube formation and migration
Molecular mechanism: circHECTD1 upregulated the level of NOTCH2 through binding with hsa-miR-335.
Survival: -
Supported No.:
 3
Description:

circHECTD1 knockdown significantly alleviated EndoMT process in HCMECs via mediation of miR-335/NOTCH2 axis. Thus, circHECTD1 might act as a potential target against IS.
Other information
Title:

Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition.

Journal: Metab Brain Dis
Published: 2022/1/21
PubMed ID: 35050446