circRNA basic information
circBase ID: -
Name: hsa_circ_PLK1
Synonym: CircPLK1
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 7474
DO name: malignant pleural mesothelioma
Disease details: malignant pleural mesothelioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MSTO-211H, H2373, H28, H2052
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: CircPLK1 knockdown suppressed the proliferation, migration, invasion and stemness of MPM cells.
Molecular mechanism: CircPLK1 contained a binding site for hsa-miR-1294 and thus bound to hsa-miR-1294 to sequester its expression. Inhibition of hsa-miR-1294 reversed the effects of circPLK1 knockdown. HMGA1 was a target of hsa-miR-1294, and circPLK1 bound to hsa-miR-1294 to increase the expression of HMGA1.
Survival: -
Supported No.:
 1
Description:

CircPLK1 was overexpressed in exosomes derived from serum of MPM patients. CircPLK1 knockdown inhibited MPM cell proliferation, migration, invasion and stemness by targeting the miR-1294/HMGA1 pathway.
Other information
Title:

CircPLK1 Acts as a Carcinogenic Driver to Promote the Development of Malignant Pleural Mesothelioma by Governing the miR-1294/HMGA1 Pathway.

Journal: Biochem Genet
Published: 2022/1/21
PubMed ID: 35050425