circRNA basic information
circBase ID: -
Name: hsa_circ_FAM64A
Synonym: CircFAM64A
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Normal breast epithelial cell line (MCF-10A), TNBC cell lines (MDAMB-231, MDA-MB-453)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: Overexpression of circFAM64A increased the proliferative, migratory, and invasive capacities of TNBC cells and promoted cell cycle progression.
Molecular mechanism: circFAM64A acted as a molecular sponge for hsa-miR-149-5p, and hsa-miR-149-5p directly targeted the Cdc10-dependent transcript 1 (CDT1) 3UTR.
Survival: poor
Supported No.:
 1
Description:

Rescue experiments demonstrated that circFAM64A sponged miR-149-5p to increase CDT1 expression, thereby promoting cellular processes in TNBC. Overall, CircFAM64A plays an oncogenic role in TNBC by interacting with miR-149-5p to increase CDT1 expression.
Other information
Title:

CircFAM64A enhances cellular processes in triple-negative breast cancer by targeting the miR-149-5p/CDT1 axis.

Journal: Environ Toxicol
Published: 2022/1/21
PubMed ID: 35048507