circRNA basic information
circBase ID: -
Name: hsa_circ_RPN2
Synonym: CircRPN2
Host Gene: hsa-miR-183-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MHCC97H, HCCLM3
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-183-5p
Biological function: CircRPN2 regulates aerobic glycolysis reprogramming in HCC cells
Molecular mechanism: CircRPN2 also acted as a competing endogenous RNA for hsa-miR-183-5p, which increases forkhead box protein O1 (FOXO1) expression to suppress glucose metabolism and tumor progression.
Survival: poor
Supported No.:
 1
Description:

The circRNA circRPN2 is a potential prognostic biomarker and therapeutic target in hepatocellular carcinoma that suppresses aerobic glycolysis and metastasis.
Other information
Title:

CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma.

Journal: Cancer Res
Published: 2022/1/21
PubMed ID: 35045986