circRNA basic information
circBase ID: -
Name: hsa_circ_FARP1
Synonym: circFARP1
Host Gene: hsa-miR-660-3p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PDAC cell lines (Panc-1, MiaPaCa-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-660-3p
Biological function: Silencing or overexpressing circFARP1 in CAFs altered the ability of CAFs to induce tumor cell stemness and GEM resistance via leukemia inhibitory factor (LIF).
Molecular mechanism: circFARP1 directly binds with caveolin 1 (CAV1) and blocks the interaction of CAV1 and the E3 ubiquitin-protein ligase zinc and ring finger 1 (ZNRF1) to inhibit CAV1 degradation, which enhances LIF secretion. In addition, circFARP1 upregulated LIF expression by sponging hsa-miR-660-3p.
Survival: poor
Supported No.:
 1
Description:

The circFARP1/CAV1/miR-660-3p/LIF axis is critical for CAF-induced GEM resistance in PDAC. Hence, circFARP1 may be a potential therapeutic target for PDAC.
Other information
Title:

circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.

Journal: Mol Cancer
Published: 2022/1/21
PubMed ID: 35045883