circRNA basic information
circBase ID: -
Name: hsa_circ_Homer1
Synonym: circHomer1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 150
DO name: disease of mental health
Disease details: reversal learning
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293 embryonic kidney human cell line, SH-SY5y human glioblastoma cell line, Neuro2a mouse neuroblastoma cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: circHomer1 knockdown (KD) within the OFC can inhibit the synaptic expression of Homer1b mRNA.
Molecular mechanism: circHomer1 directly binds to Homer1b mRNA and that Homer1b-specific KD increases synaptic circHomer1 levels and improves OFC-mediated behavioral flexibility.
Survival: -
Supported No.:
 1
Description:

Taken together, our data provide mechanistic insights into the importance of circRNAs in brain function and disease.
Other information
Title:

A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.

Journal: Cell Rep
Published: 2022/1/20
PubMed ID: 35045295