circRNA basic information
circBase ID: -
Name: hsa_circ_MET
Synonym: CircMET
Host Gene: hsa-miR-1197
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T, HK-2, ACHN, 786-O, Xp11.2 tRCC, UOK120, UOK109
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1197
Biological function: overexpression of circMET significantly promoted the growth of NONO-TFE3 tRCC.
Molecular mechanism: Mechanistic studies revealed that circMET was delivered to cytosol by YTHDC1 in N6-methyladenosine (m6A)-depend manner. CircMET enhances mRNA decay of CDKN2A by direct interaction and recruitment of YTHDF2. Meanwhile, circMET competitively absorbed hsa-miR-1197 and prevented those from SMAD3 mRNA.
Survival: -
Supported No.:
 1
Description:

CircMET promotes the development of NONO-TFE3 tRCC, and the regulation to both CDKN2A and SMAD3 of circMET was revealed. CircMET has the potential to serve as a novel target for the molecular therapy of NONO-TFE3 tRCC as well as the other cancer with high-expressing circMET.
Other information
Title:

CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3.

Journal: Mol Cancer
Published: 2022/1/20
PubMed ID: 35042525