circRNA basic information
circBase ID: hsa_circ_0001795
Name: -
Synonym: CircRNA_0001795
Host Gene: hsa-miR-339-5p
 
 
 
Disease basic information
DO ID:
 11476
DO name: osteoporosis
Disease details: osteoporosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bone marrow mesenchymal stem cells (hBMSCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-339-5p
Biological function: Everexpression of circ_0001795 could significantly promote the osteogenic differentiation of hBMSCs.
Molecular mechanism: MiRNA-339-5p (hsa-miR-339-5p) was identified as a target of circ_0001795, and hsa-miR-339-5p mimic attenuated the effect of circ_0001795 overexpression. hsa-miR-339-5p downregulated yes-associated protein 1 (YAP1), which mediates the effect of circ_0001795 overexpression.
Survival: -
Supported No.:
 2
Description:

Overall, this study uncovered the role of circ_0001795/miR-339-5p/YAP1 axis in regulating osteogenic differentiation, indicating that targeting Circ_0001795 could serve as a novel therapeutic target for OP.
Other information
Title:

CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression.

Journal: Bioengineered
Published: 2022/1/19
PubMed ID: 35040370