circRNA basic information
circBase ID: -
Name: hsa_circ_KIF2A
Synonym: circKIF2A
Host Gene: hsa-miR-377-3p
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SK-N-AS, LAN-6
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-377-3p
Biological function: the silencing of circKIF2A inhibited cell proliferation, migration, invasion, and glycolysis, boosted apoptosis in neuroblastoma cells in vitro, and blocked the growth of subcutaneously transplanted tumors in nude mice.
Molecular mechanism: circKIF2A could work as a sponge of hsa-miR-377-3p to enhance PRPS1 expression.
Survival: -
Supported No.:
 2
Description:

CircKIF2A knockdown impedes cell proliferation, metastasis, and glycolysis partly by regulating the miR-377-3p/PRPS1 axis, suggesting that targeting circKIF2A can be a feasible therapeutic strategy for neuroblastoma.
Other information
Title:

Circular RNA circKIF2A Contributes to the Progression of Neuroblastoma Through Regulating PRPS1 Expression by Sponging miR-377-3p.

Journal: Biochem Genet
Published: 2022/1/19
PubMed ID: 35039981