circRNA basic information
circBase ID: hsa_circ_0000467
Name: -
Synonym: Circ_0000467
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (HCT116, LoVo), human normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: Silencing of circ_0000467 could inhibit the proliferation, migration, invasion, and glycolysis and accelerated the apoptosis of CRC cells in vitro and hindered tumor growth in vivo.
Molecular mechanism: circ_0000467 directly interacted with hsa-miR-330-5p and circ_0000467 depletion inhibited CRC cell malignant progression by regulating hsa-miR-330-5p. Furthermore, TYRO3 was a target of hsa-miR-330-5p and circ_0000467 upregulated TYRO3 expression by sponging hsa-miR-330-5p.
Survival: -
Supported No.:
 4
Description:

Circ_0000467 knockdown suppressed CRC cell malignant development through modulating the miR-330-5p/TYRO3 network, providing a novel molecular target of CRC therapy.
Other information
Title:

Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.

Journal: Biochem Genet
Published: 2022/1/19
PubMed ID: 35039980