circRNA basic information
circBase ID: hsa_circ_0004354
Name: -
Synonym: Circ_0004354
Host Gene: hsa-miR-345-3p
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: primary human NPCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-345-3p
Biological function: Accumulating studies have reported PANoptosis is composed of apoptosis, pyroptosis, and necroptosis.
Molecular mechanism: Circ_0004354 might compete with circ_0040039 to induce the development of IVDD by modulating hsa-miR-345-3p-FAF1/TP73 axis-mediated PAoptosis, inflammatory response, growth inhibition, and ECM degradation of NPCs.
Survival: -
Supported No.:
 1
Description:

these findings offer a novel insight into the circRNAs-mediated posttranscriptional regulatory network in IVDD, contributing to further clarification of the pathological mechanism of IVDD to develop a promising therapeutic target for IVDD diseases.
Other information
Title:

Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.

Journal: Oxid Med Cell Longev
Published: 2022/1/19
PubMed ID: 35039758