circRNA basic information
circBase ID: -
Name: hsa_circ_NFIB
Synonym: CircNFIB
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4928
DO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ICC cell lines (HuCCT1, HCCC9810, RBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: cNFIB inhibited the proliferation and metastasis of ICC cells in vitro and in vivo.
Molecular mechanism: cNFIB competitively interacted with MEK1, which induced the dissociation between MEK1 and ERK2, thereby resulting in the suppression of ERK signaling and tumor metastasis.
Survival: better
Supported No.:
 1
Description:

Our findings identified that cNFIB played a key role in ICC growth and metastasis by regulating MEK1/ERK signaling. Given the efficacy of cNFIB modulation on ICC suppression and trametinib sensitivity, cNFIB appears to be a potential therapeutic molecule for ICC treatment.
Other information
Title:

CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.

Journal: Mol Cancer
Published: 2022/1/19
PubMed ID: 35039066