circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circFOXO3
Host Gene: hsa-miR-545-3p, hsa-miR-506-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (HBE), NSCLC cell lines (CALU3, CALU6, A549, H1229)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-545-3p, hsa-miR-506-3p
Biological function: Knockdown of circFOXO3 not only inhibited NSCLC cell proliferation, migration and invasion in vitro but also suppressed tumor growth in vivo.
Molecular mechanism: circFOXO3 on NSCLC was dependent on sponging hsa-miR-545-3p and hsa-miR-506-3p. Further bioinformatic analysis and biochemistry experiments revealed that hsa-miR-545-3p and hsa-miR-506-3p regulated the expression of a family member of high-mobility group box, HMGB3.
Survival: -
Supported No.:
 2
Description:

Here, we show thatcircFOXO3 in NSCLC promotes the proliferation, migration and invasion of NSCLC cells, thereby promoting tumor growth. We further find that circFOXO3 sponges miR-545-3p/miR-506-3p that bind to 3-UTR of HMGB3 mRNA, which constitutes the major network fulfilling the circFOXO3s promoting effect. Therefore, we proposed that circFOXO3 could be a potential therapeutic target for NSCLC.
Other information
Title:

Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p.

Journal: Tissue Cell
Published: 2022/1/18
PubMed ID: 35038619