circRNA basic information
circBase ID: -
Name: hsa_circ_TRPS1
Synonym: circTRPS1
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human epithelial (SV-HUC-1), BCa cell lines (RT4, UM-UC-3, T24, 5637, J82)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-141-3p
Biological function: Exosome-derived circTRPS1 promoted BCa cell proliferation and invasion_n_itro
Molecular mechanism: We identified that exosome-derived hsa_circ_0085361 (circTRPS1) was correlated with aggressive phenotypes of BCa cells via sponging hsa-miR-141-3p. Metabolomics and RNA sequencing (RNA-seq) identified GLS1-mediated glutamine metabolism was involved in circTRPS1-mediated alterations.
Survival: poor
Supported No.:
 1
Description:

exosome-derived circTRPS1 from BCa cells can modulate the intracellular reactive oxygen species (ROS) balance and CD8+ T cell exhaustion via the circTRPS1/miR141-3p/GLS1 axis..
Other information
Title:

Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments.

Journal: Mol Ther
Published: 2022/1/18
PubMed ID: 35038580