circRNA basic information
circBase ID: -
Name: hsa_circ_LDLRAD3
Synonym: LDLRAD3
Host Gene: hsa-miR-20a-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 4 human NSCLC cell lines (A549, H1299, HCC827, Calu-3), 1 human bronchial epithelial cell line (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-20a-5p
Biological function: Promotes the proliferative, migrative, and invasive abilities of A549 and H1299 cell lines
Molecular mechanism: LDLRAD3 was verified to sponge hsa-miR-20a-5p and hsa-miR-20a-5p targeted SLC7A5.
Survival: -
Supported No.:
 1
Description:

We concluded that LDLRAD3 exerted oncogenic effects via the miR-20a-5p-SLC7A5 axis to activate the mTORC1 signaling pathway in NSCLC. Our findings enlightened that LDLRAD3 could become a potential therapeutic target in the treatment and management of NSCLC.
Other information
Title:

circRNA LDLRAD3 Enhances the Malignant Behaviors of NSCLC Cells via the miR-20a-5p-SLC7A5 Axis Activating the mTORC1 Signaling Pathway.

Journal: J Healthc Eng
Published: 2022/1/18
PubMed ID: 35035814