circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_102049
Host Gene: hsa-miR-214-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HepG2 cells, Huh-7 cells, HEK-293_ cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-214-3p
Biological function: hsa_circRNA_102049 over-expression promoted the sensitivity of HepG2 cells and Huh-7 cells to sorafenib
Molecular mechanism: hsa_circRNA_102049 up-regulated the expression of_ELN_ene by sponging hsa-miR-214-3p.
Survival: -
Supported No.:
 1
Description:

These findings support targeting of hsa_circRNA_102049 and RELN in sorafenib-treated HCC cells as a novel intervention, which is expected to overcome sorafenib resistance of HCC cells.
Other information
Title:

The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression.

Journal: Bioengineered
Published: 2022/1/18
PubMed ID: 35034536