circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: Circ-FAT1
Host Gene: hsa-miR-619-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (HCT116, SW480), normal colonic epithelial cell (NCM460), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-619-5p
Biological function: knockdown of circ-FAT1 or FOSL2 suppressed CRC cell apoptosis, migration, invasion, and angiogenesis, but induced cell apoptosis in vitro.
Molecular mechanism: circ-FAT1 acted as a sponge for hsa-miR-619-5p to up-regulate the expression of FOSL2, which was confirmed to be a target of hsa-miR-619-5p.
Survival: -
Supported No.:
 2
Description:

Circ-FAT1 knockdown repressed FOSL2 expression by sponging miR-619-5p to suppress CRC tumorigenesis, providing a potential approach for CRC therapeutics.
Other information
Title:

Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.

Journal: Biochem Genet
Published: 2022/1/17
PubMed ID: 35034245