circRNA basic information
circBase ID: hsa_circ_0000231
Name: hsa_circ_ARHGAP12
Synonym: circ_0000231
Host Gene: hsa-miR-375
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colorectal cancer cell lines (SW480, SW620, HCT116, HT29, RKO, LS174T, COLO-215, HCT8, LoVo)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-375
Biological function: Functional analysis indicated that inhibition of hsa_circ_0000231 in CRC cell lines could suppress CRC cell proliferation as well as tumorigenesis in vitro and in vivo.
Molecular mechanism: The mechanistic analysis showed that hsa_circ_0000231 might, on the one hand, act as a competing endogenous RNA of hsa-miR-375 to promote cyclin D2 (CCND2) and, on the other hand, bind to the IGF2BP3 protein to prevent CCND2 degradation.
Survival: poor
Supported No.:
 2
Description:

The findings suggested that hsa_circ_0000231 facilitated CRC progression by sponging miR-375 or binding to IGF2BP3 to modulate CCND2, implying that hsa_circ_0000231 might be a potential new diagnostic and therapeutic biomarker of CRC.
Other information
Title:

hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway.

Journal: Cancer Cell Int
Published: 2022/1/17
PubMed ID: 35033075