circRNA basic information
circBase ID: -
Name: hsa_circ_MARS
Synonym: circMARS
Host Gene: -
 
 
 
Disease basic information
DO ID:
 399
DO name: tuberculosis
Disease details: Tuberculosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HL_7702_uman hepatocytes
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: In addition to the value assessment of circMARS in patients using a receiver operating characteristic (ROC) curve, cell experiments were also performed under the guidance of bioinformatics analyses.
Molecular mechanism: circMARS acts as a miRNA sponge by binding to miRNAs. Compared with the blank group, the expressions of circMARS, KMT2C gene, and EGFR protein in the ADLI group were increased, while hsa-miR-6808-5p, hsa-miR-6874-3p, and hsa-miR-3157-5p were decreased.
Survival: -
Supported No.:
 1
Description:

A self-controlled cohort of 35 participants was used to verify the circMARS-miR-6808-5p/-6874-3p/-3157-5p-KMT2C-EGFR function axis. Therefore, circMARS may participate in the compensatory repair mechanism of ADLI through the function axis, and may be a potential biomarker for ADLI diagnosis in TB patients.
Other information
Title:

Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti-tuberculosis drug-induced liver injury.

Journal: J Cell Mol Med
Published: 2022/1/16
PubMed ID: 35032098