circRNA basic information
circBase ID: hsa_circ_0032683
Name: hsa_circ_NEK9
Synonym: -
Host Gene: hsa-miR-338-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Seven human HCC cell lines (HCCLM3, MHCC97-L, Hep3B, SMMC-7721, Huh7, Bel-7402, MHCC97-H), one standard liver cell line (WRL68)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-338-5p
Biological function: In vitro and in vivo functional tests revealed that hsa_circ_0032683 could inhibit HCC cells proliferation and promote their apoptosis.
Molecular mechanism: hsa_circ_0032683 primarily exists in the cytoplasm and competes with microRNA-338-5p (hsa-miR-338-5p) to regulate reticulon 4(RTN4).
Survival: -
Supported No.:
 1
Description:

Our experiments revealed that hsa_circ_0032683 receded the proliferation ability of HCC via ceRNA (competing endogenous RNAs) mechanism, which provided potential biomarkers and therapeutic targets for HCC patients.
Other information
Title:

Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p.

Journal: Bioengineered
Published: 2022/1/16
PubMed ID: 35030979