circRNA basic information
circBase ID: hsa_circ_0019693
Name: -
Synonym: Circ_0019693
Host Gene: hsa-miR-942-5p
 
 
 
Disease basic information
DO ID:
 11476
DO name: osteoporosis
Disease details: osteoporosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human BMSCs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-942-5p
Biological function: Circ_0019693 overexpression enhanced the activity of ALP and the expression of RUNX2, OPN and OCN, and its overexpression also promoted angiogenesis
Molecular mechanism: hsa-miR-942-5p was ensured to be a target of circ_0019693, and hsa-miR-942-5p enrichment reversed the effects of circ_0019693. In addition, PCP4 was a target of hsa-miR-942-5p,
Survival: -
Supported No.:
 1
Description:

circ_0019693 promotes BMSC osteogenic differentiation osteogenesis-coupled angiogenesis via regulating miR-942-5p-targeted PCP4, thus blocking the development of OP.
Other information
Title:

Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis.

Journal: Bioengineered
Published: 2022/1/16
PubMed ID: 35030971