circRNA basic information
circBase ID: hsa_circ_0007841
Name: hsa_circ_SEC61A1
Synonym: -
Host Gene: hsa-miR-660-5p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MM cell lines (RPMI-8226, U266), normal plasma cell line (nPCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK6
Associated microRNA: hsa-miR-660-5p
Biological function: promote cell proliferation and invasion and inhibit apoptosis
Molecular mechanism: sponged hsa-miR-660-5p to positively regulate CDK6 expression, miRNA sponge
Survival: -
Supported No.:
 5
Description:

Our study manifested that circ_SEC61A1 could accelerate MM progression at least partially through modulating miR-660-5p/CDK6 axis.
Other information
Title:

Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis.

Journal: Leuk Res
Published: 2022/1/15
PubMed ID: 35030455