circRNA basic information
circBase ID: hsa_circ_0005239
Name: hsa_circ_GFRA1
Synonym: -
Host Gene: hsa-miR-34a
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human mammary epithelial cell lines (MCF10A, 184A1), breast cancer cell lines (SKBR3, T47D, BT474, MCF-7, BT-483, BT-20, BT549, MDA-MB-468, MDA-MB-231)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34a
Biological function: promoting cell proliferation and inhibiting cell apoptosis
Molecular mechanism: regulate GFRA1 expression through sponging hsa-miR-34a
Survival: poor
Supported No.:
 3
Description:

CircGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in triple negative breast cancer (TNBC). circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy.
Other information
Title:

circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.

Journal: J Exp Clin Cancer Res
Published: 2017/10/19
PubMed ID: 29037220