circRNA basic information
circBase ID: -
Name: hsa_circ_CUL2
Synonym: circCUL2
Host Gene: hsa-miR-208a-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human colorectal cancer cell lines (HT290, HCT116, SW480, SW620), normal colonic epithelial cells (FHC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-208a-3p
Biological function: Forcing expression of circCUL2 inhibited proliferation ability, induced apoptosis, and autophagy in colorectal cancer cells.
Molecular mechanism: Luciferase assay verified that hsa-miR-208a-3p could bind with circCUL2/PPP6C. Overexpression of circCUL2 could inhibit cancer progression via targeting the hsa-miR-208a-3p/PPP6C signal pathway.
Survival: -
Supported No.:
 1
Description:

CircCUL2 participates in progression via the miR-208a-3p/PPP6C axis in colorectal cancer. CircCUL2 would be an underlying target for the diagnosis and therapy of colorectal cancer.
Other information
Title:

Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C.

Journal: Aging (Albany NY)
Published: 2022/1/15
PubMed ID: 35027503