circRNA basic information
circBase ID: -
Name: hsa_circ_TIAM1
Synonym: circTIAM1
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PTC cell lines (TPC-1, B-CPAP, KTC-1, IHH-4, K1), human thyroid follicular epithelial cell line (Nthy-ori 3-1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-646
Biological function: association with apoptosis, proliferation, and migration of PTC cells in vitro and in vivo.
Molecular mechanism: circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting hsa-miR-646 and heterogeneous ribonucleoprotein A1.
Survival: -
Supported No.:
 1
Description:

Our results reveal an important oncogenic role of circTIAM1 in PTC and may represent a potentially therapeutic target against PTC progression.
Other information
Title:

CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway.

Journal: Cell Death Discov
Published: 2022/1/14
PubMed ID: 35022405