circRNA basic information
circBase ID: -
Name: hsa_circ_PIK3C2A
Synonym: CircPIK3C2A
Host Gene: hsa-miR-877-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T, human GBM cell lines (U87-MG, U251-MG, A172, T98G), normal brain glia cell line (HEB)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-877-5p
Biological function: The ectopic expression of circPIK3C2A promoted the proliferation, invasion and clonal formation of glioblastoma cells
Molecular mechanism: CircPIK3C2A function as competitive endogenous RNA_ia_ponging hsa-miR-877-5p through certain binding sites, thereby modulating the expression of FOXM1.
Survival: -
Supported No.:
 1
Description:

circPIK3C2A functions as ceRNA by mediating miR-877-5p/FOXM1 axis, providing a novel perspective of applying CircPIK3C2A in the clinical intervention of glioblastoma in the future.
Other information
Title:

CircPIK3C2A Facilitates the Progression of Glioblastoma via Targeting miR-877-5p/FOXM1 Axis.

Journal: Front Oncol
Published: 2022/1/11
PubMed ID: 35004326