circRNA basic information
circBase ID: -
Name: hsa_circ_METTL3
Synonym: circMETTL3
Host Gene: hsa-miR-34c-3p
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human mammary epithelial (HME) cell lines (MCF10A, 184A1), TNBC cell lines (MDA-MB-231, BT-549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34c-3p
Biological function: circMETTL3 inhibits cell proliferation, invasion, tumor growth and metastasis
Molecular mechanism: circMETTL3 could act as a sponge for hsa-miR-34c-3p regulatingwe found that circMETTL3 could act as a sponge for hsa-miR-34c-3p and inhibits cell proliferation, invasion, tumor growth and metastasis by up-regulating the expression of hsa-miR-34c-3p target gene METTL3. the expression of hsa-miR-34c-3p target gene METTL3.
Survival: -
Supported No.:
 1
Description:

In conclusion, our study demonstrates the functional importance and regulatory mechanism of METTL3 in suppressing the tumor growth of TNBC.
Other information
Title:

METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer.

Journal: Front Oncol
Published: 2022/1/11
PubMed ID: 35004298