circRNA basic information
circBase ID: -
Name: hsa_circ_N4bp1
Synonym: circN4bp1
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 11394
DO name: adult respiratory distress syndrome
Disease details: acute respiratory distress syndrome
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: PBMC and monocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: METTL3
Associated microRNA: hsa-miR-138-5p
Biological function: Knockdown of circN4bp1 inhibited the lung injury and improved the long-time survival through blunting the M1 macrophage activation in cecal ligation and puncture- (CLP-) induced ARDS mice.
Molecular mechanism: CircN4bp1 affected macrophage differentiation by binding to miR-138-5p, thus regulating the expression of EZH2 in vivo and ex vivo.
Survival: poor
Supported No.:
 1
Description:

circN4bp1 can function as a miR-138-5p sponge for the modulation of macrophage polarization through regulation the expression of EZH2 and may serve as a potential target and/or prognostic marker for ARDS patients following sepsis.
Other information
Title:

CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis.

Journal: Mediators Inflamm
Published: 2022/1/11
PubMed ID: 35002536