circRNA basic information
circBase ID: hsa_circ_0092291
Name: -
Synonym: Circ_0092291
Host Gene: hsa-miR-626
 
 
 
Disease basic information
DO ID:
 7693
DO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human aortic vascular smooth muscle cell line (T/G HA-VSMC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-626
Biological function: Inflammatory response and cell apoptosis were reduced while angiopoiesis and ECM level were facilitated after overexpression of circ_0092291 in Ang II-treated T/G HA-VSMC cells.
Molecular mechanism: circ_0092291 could suppress the Ang II-induced cell dysfunction by targeting the hsa-miR-626/COL4A1 signaling axis.
Survival: -
Supported No.:
 1
Description:

Circ_0092291 might improve the diagnosis and treatment of AAA.Key Points.Biological mechanism, Apoptosis, Molecular target.
Other information
Title:

Circ_0092291 attenuates angiotensin II-induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis.

Journal: J Physiol Biochem
Published: 2022/1/9
PubMed ID: 34997455