circRNA basic information
circBase ID: -
Name: hsa_circ_CRIM1
Synonym: circRNA-CRIM1
Host Gene: hsa-miR-182
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human invasive bladder cancer cell line (UMUC3, T24), endothelial cell line (HUVEC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-182
Biological function: The overexpression of circRNA CRIM1 reduced migration and invasion processes in bladder cancer cells.
Molecular mechanism: After circRNA CRIM1 was overexpressed, the hsa-miR-182 was significantly down-regulated. The expression levels of Foxo3a mRNA and proteins were up-regulated after hsa-miR-182 silencing of bladder cancer cell line UMUC3. hsa-miR-182 silencing inhibited invasion and migration of cancer cells to some extent. In bladder cancer cells and tissues, CRIM1 and Foxo3a were significantly down-regulated, hsa-miR-182 was significantly up-regulated.
Survival: -
Supported No.:
 1
Description:

circRNA CRIM1 regulated the migration and invasion of bladder cancer by targeting the miR182/Foxo3a axis.
Other information
Title:

circRNA CRIM1 regulates the migration and invasion of bladder cancer by targeting miR182/Foxo3a axis.

Journal: Clin Transl Oncol
Published: 2022/1/8
PubMed ID: 34994952