circRNA basic information
circBase ID: hsa_circ_0007385
Name: -
Synonym: Circ_0007385
Host Gene: hsa-miR-493-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NSCLC cell lines (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-493-3p
Biological function: circ_0007385 deficiency inhibited cell proliferation and stemness, whereas it promoted cell apoptosis in NSCLC cells.
Molecular mechanism: circ_0007385 acted as a hsa-miR-493-3p sponge to modulate RAB22A expression.
Survival: -
Supported No.:
 5
Description:

Circ_0007385 promoted NSCLC progression by sponging miR-493-3p to increase RAB22A expression, which also offered an underlying targeted therapy for NSCLC treatment.
Other information
Title:

Circ_0007385 regulates cell proliferation, apoptosis and stemness via targeting miR-493-3p/RAB22A axis in non-small cell lung cancer.

Journal: Thorac Cancer
Published: 2022/1/7
PubMed ID: 34989145