circRNA basic information
circBase ID: hsa_circ_0003602
Name: hsa_circ_SMARCC1
Synonym: -
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: AML cell lines (HL-60, K562, THP-1), an immortalized human bone marrow stromal cell line (HS-5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-502-5p
Biological function: Knockdown of hsa_circ_0003602 in AML cell lines induced the inhibition of proliferation, migration, and invasion and caused apoptosis.
Molecular mechanism: Hsa_circ_0003602 sequestered hsa-miR-502-5p by functioning as a competitive endogenous RNA (ceRNA), thereby regulating IGF1R expression. Hsa_circ_0003602 acted as a tumor promoter in AML via hsa-miR-502-5p/IGF1R axis.
Survival: poor
Supported No.:
 1
Description:

hsa_circ_0003602, miR-502-5p, and IGF1R might form a regulatory axis to affect the carcinogenicity of AML cells and provide potential targets for the treatment of AML.
Other information
Title:

Homo sapiens circular RNA 0003602 (Hsa_circ_0003602) accelerates the tumorigenicity of acute myeloid leukemia by modulating miR-502-5p/IGF1R axis.

Journal: Mol Cell Biochem
Published: 2022/1/7
PubMed ID: 34988853