circRNA basic information
circBase ID: hsa_circ_0026134
Name: -
Synonym: Circ_0026134
Host Gene: hsa-miR-3619-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cells (BEAS_2B), NSCLC cells (H520, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3619-5p
Biological function: Reduced circ_0026134 expression or miR-3619-5p overexpression inhibited NSCLC cell colony formation, migration, invasion, glycolysis and promoted cell apoptosis in vitro.
Molecular mechanism: circ_0026134 directly targeted hsa-miR-3619-5p, and circ_0026134 regulated CHAF1B expression through hsa-miR-3619-5p.
Survival: -
Supported No.:
 3
Description:

Our study identified a novel regulatory mechanism, the circ_0026134/miR-3619-5p/CHAF1B axis, for the oncogenic role of circ_0026134 in NSCLC, highlighting circ_00261345 inhibition as a potential therapeutic method against NSCLC.
Other information
Title:

Circ_0026134 promotes NSCLC progression by the miR-3619-5p/CHAF1B axis.

Journal: Thorac Cancer
Published: 2022/1/6
PubMed ID: 34985193