circRNA basic information
circBase ID: hsa_circ_0078607
Name: -
Synonym: Circ_0078607
Host Gene: hsa-miR-32-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OC cell lines (HEY, ES-2), normal epithelial ovarian cell line (IOSE80)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-32-5p
Biological function: Overexpressed circ_0078607 and SIK1 could inhibit OC cell proliferation, migration, invasion, and promote apoptosis.
Molecular mechanism: hsa-miR-32-5p could be sponged by circ_0078607, and its overexpression could reverse the suppressive effect of circ_0078607 on OC progression. Furthermore, SIK1 was a target of hsa-miR-32-5p, and circ_0078607 could regulate SIK1 by sponging hsa-miR-32-5p.
Survival: -
Supported No.:
 4
Description:

Circ_0078607 could serve as a sponge of miR-32-5p to regulate SIK1 expression, thereby inhibiting OC progression.
Other information
Title:

Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.

Journal: J Ovarian Res
Published: 2022/1/6
PubMed ID: 34983607